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However, development of antimicrobial resistance in bacteria may parallel the use of fluoroquinolones. Fluoroquinolones (FQs) are important drugs for treating salmonellosis in both humans and animals 3, 4, 5, 6. In conclusion, short time treatment (7 days) of enrofloxacin at high dosage (100 mg/kg b.w.) could be effective in treating Salmonella infection while minimizing resistance selection in both Salmonella and coliforms.Īs a zoonotic foodborne pathogen, Salmonella enterica has been widely recognized as one of the most common causes of gastroenteritis in humans 1, 2. was not able to eliminate Salmonella and selected coliforms with slight decreased susceptibility (MIC ENR = 0.25 mg/L). Low frequency (5–9.5%) of resistant coliforms was selected (days 39–42). However upon cessation of medication, Salmonella repopulated chickens and persisted till the end with reduced susceptibility (MIC CIP = 0.03–0.25 mg/L). PK/PD based dosage (4 mg/kg b.w.) effectively reduced Salmonella for the first treatment duration. of enrofloxacin completely eradicated Salmonella, but resistant coliforms (4.0–60.8%) were selected from the end of the second round’s withdrawal period till the end of the experiment (days 28–42). Treatment duration was three rounds of 7-day treatment alternated with 7-day withdrawal. Effect of enrofloxacin treatments on clearance of Salmonella in experimentally infected chickens and simultaneously resistance selection in Salmonella and coliforms were evaluated in three treatment groups (100, PK/PD designed dosage of 4, 0.1 mg/kg b.w.) and a control group.
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To investigate the optimal dosage which can improve clinical efficacy and minimize resistance, pharmacokinetics/pharmacodynamics model of enrofloxacin was established.